Midfielder Kwasi Donsu scored the only goal of the match as Medeama posted a 1-0 win over lower division side Achiken FC in a friendly on Sunday.
The Mauve and Yellows continued their impressive form in October with another routine win on the road.
Donsu rattled home the only goal of the match in Prestea as coach Samuel Boadu continues a build-up of his team.
The two-time FA Cup winners beat Karela United 2-0 on their last trip.